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Jeff Ackerman Initiates Coverage On (PDSB) Starting This Morning
—Wednesday, October 29, 2025
(PDSB) Comes Backed By Several Potential Catalysts—But Here's
What We Can Tell You Right Now:
Analyst Attention: Recent Coverage Highlights Projected Upside Potential
Between 370% And 1,200% For (PDSB).
Survival Outperformance: Median Overall Survival Reached 39.3 Months For (PDSB), Far Exceeding Current Standards.
Tumor Regression: Several Patients Saw Complete Or Near-Complete Shrinkage Lasting Beyond 20 Months With (PDSB).
Phase 3 Momentum: A Global Pivotal Study (VERSATILE-003) Is Underway For (PDSB) With Survival As The Primary Focus.
Pull Up (PDSB) Before The Bell Rings…
October 29, 2025
Early Coverage | See Why (NASDAQ: PDSB) Just Landed On This Morning's Radar Dear Reader, Last night we told you something was coming today. This morning, we're ready to pull back the curtain. The name is PDS Biotechnology Corporation (NASDAQ: PDSB) — a clinical-stage U.S. biotech developing precision-engineered immunotherapies that may help the body recognize and destroy cancer cells with extraordinary accuracy. For months, whispers about this company's data have been circulating quietly through the oncology community. But now, with new clinical results and a pivotal trial underway, the story is beginning to attract far broader attention. Analysts Are Taking Notice
It's not just scientists paying attention anymore. Recent coverage reported by TipRanks from multiple research firms has started highlighting (PDSB) with target ranges suggesting the potential for significant upside from its current levels: - James Molloy of Alliance Global Partners issued a $4.50 target, which suggests 370% upside potential.
- Mayank Mamtani of B. Riley Securities set a $5 target, suggesting more than 420% upside potential.
- Joseph Pantginis of H.C. Wainwright & Co. maintained a $13 target, pointing to over 1,200% upside potential.
These aren't casual mentions — they reflect detailed analysis of (PDSB)'s clinical progress, data integrity, and advancing Phase 3 program. It's uncommon to see three independent firms converge on such aggressive targets this early in the clinical cycle. But taken together, they underscore a growing recognition of how far (PDSB) has come — and what could lie ahead as its pivotal trial advances. For long-time biotech watchers, this is often the turning point — when a quiet clinical name transitions from niche scientific circles into broader market awareness. And once you review the data behind it, it's clear why the attention is building. A Standout in a Rapidly Changing Field
Cancer immunotherapy isn't new — but precision immunotherapy is changing everything. While many treatments focus on stimulating immune activity in general, (PDSB)'s platform, known as Versamune®, is designed to trigger a specific type of T-cell activation. These immune cells — the body's natural "seek and destroy" agents — are taught to recognize particular cancer-linked proteins such as HPV16, a driver of one of the fastest-growing cancer types in the U.S. and Europe. That level of precision could mark a turning point in how immune-based treatments are designed, tested, and delivered. The Data That's Turning Heads
In a recently completed mid-stage study known as VERSATILE-002, patients treated with (PDSB)'s lead candidate achieved a median overall survival of 39.3 months — more than double the 12–18 months typically seen under current standards of care. Even more striking, 21% of patients experienced complete or near-complete tumor regression, with responses lasting beyond 20 months.
Those results were shared at the 2025 ASCO Congress, one of the largest oncology conferences in the world — and they quickly became one of the most talked-about presentations in the head and neck cancer track. For researchers and clinicians, the data reinforced something that's been quietly building for some time: (PDSB) may be charting a different course in immunotherapy design. From Early Promise to Phase 3 Reality
Strong data is only the beginning. What comes next often determines whether a therapy becomes part of future medical practice. (PDSB) is now advancing into a Phase 3 pivotal trial known as VERSATILE-003 — a global, randomized study designed to compare the company's therapy directly against today's leading treatment standards. And it's not doing it alone. The study is being conducted in collaboration with some of the most respected names in cancer research — including MD Anderson, Mayo Clinic, and the National Cancer Institute.
These are the kinds of partnerships that rarely align behind early-stage companies unless the science is compelling enough to warrant attention. A Platform With Broader Reach
While the lead focus is HPV16-positive head and neck cancer, the potential reach extends far beyond that. (PDSB)'s Versamune® platform is already being studied in multiple cancers — including cervical, colorectal, and prostate — through trials sponsored by leading research centers and national programs. Each new dataset adds another piece to the same puzzle: can the immune system, if properly trained, consistently recognize and eliminate tumors across a range of diseases? That's the question driving the company's entire development pipeline. Why This Story Matters Right Now
HPV16-positive head and neck cancer is one of the fastest-growing cancer segments in developed nations — and as of today, no targeted therapy exists for this specific patient group. That's the void (PDSB) is working to fill. The company's goal is straightforward: bring a non-chemo, immune-targeted approach that can extend survival, improve quality of life, and potentially set a new standard of care. The path ahead is ambitious — but so far, the early milestones have been met with precision and progress. 
Looking Ahead
The company expects enrollment for the pivotal trial to complete in the first half of 2026, with additional clinical updates anticipated throughout 2025. Meanwhile, parallel programs involving the company's antibody-drug conjugate (ADC) technology are moving through Phase 2 testing in colon and prostate cancer, supported by third-party funding and collaborative research partnerships. This combination of clinical depth, institutional backing, and scientific momentum is precisely what makes this morning's reveal one to keep on your radar. 1. Analyst Attention: Recent coverage outlines projected upside potential in the 370%–1,200% range for (PDSB). 2. Survival Outperformance: In a mid-stage study, median overall survival reached 39.3 months for (PDSB), compared with 12–18 months under current standards. 3. Tumor Regression: Several patients experienced complete or near-complete shrinkage with durability beyond 20 months on (PDSB)'s lead program. 4. Phase 3 Momentum: A pivotal, randomized study (VERSATILE-003) is underway for (PDSB), designed with overall survival as the primary endpoint. 5. Top Institutions: Major cancer centers—MD Anderson, Mayo Clinic, and the National Cancer Institute—are collaborators on (PDSB) programs. 6. Encouraging Trial Safety: Treatment-related Grade 3/4 events were reported at 9%/1% in the Phase 2 experience for (PDSB). 7. Clear Unmet Need: HPV16+ head and neck cancer lacks targeted options, with poor outcomes under current care—precisely the setting (PDSB) targets. Pull Up (PDSB) Before The Bell Rings…
When you step back and look at the full picture, the story behind (PDSB) becomes difficult to ignore. You have analyst coverage projecting 370%–1,200% upside potential, based on expanding clinical visibility… Survival data showing outcomes that far exceed today's benchmarks… Tumor regression rates that continue to stand out in peer-reviewed settings… And a Phase 3 pivotal trial already in motion — supported by some of the most respected names in oncology, including MD Anderson, Mayo Clinic, and the National Cancer Institute. All this is paired with encouraging safety data, a clear unmet medical need, and a platform built on precision immunotherapy — a space that's rapidly defining the next chapter of cancer treatment. For now, all signs point to a program with both depth and direction. We have all eyes on (PDSB) right now. Take a look at (PDSB) this morning before the bell rings. Also, keep a lookout for my next update — it could be here within the next 60-90 minutes.. Sincerely,
Jeff Ackerman
Managing Editor
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