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Jeff Ackerman Brings MAIA Biotechnology (NYSE American: MAIA) Back To The Watchlist Starting This Morning—Tuesday, October 7, 2025.
Here's Why (MAIA) Just Landed On Our Radar…
Analyst Targets Reaching As High As $14, Suggesting Over 700% Upside
Potential From Recent Levels.
Small Float Under 25M Shares Could Set The Stage For Big Move
Potential If Demand Begins To Shift.
Under The Radar And Still Trending Below $2
Take A Look At (MAIA) Before The Bell Rings…
October 7, 2025
Watch Closely | (NYSE: MAIA) Lands Back On Our Radar This Morning—Here's Why Dear Reader, Every now and then, a clinical-stage company begins to separate itself from the rest of the pack. MAIA Biotechnology (NYSE American: MAIA) is quickly becoming one of those names. Its lead program, THIO, is the first telomere-targeting agent of its kind—showing promise in disrupting cancer cell survival while enhancing immune activity. Since our previous coverage, (MAIA) has made an approximate 24% move, reflecting growing attention as fresh data and funding milestones come into focus. But here's what stands out: (MAIA) has fewer than 25M shares in its public float according to MarketWatch. Companies with small floats have the potential for big moves if demand starts to shift. meaning And despite that, the company remains below $2, largely unnoticed by the broader market.
All of this comes as analyst coverage intensifies and survival data continue to outperform typical benchmarks. Taken together, it's the kind of setup that rarely stays overlooked for long. Analysts have taken notice. Diamond Equity Research highlighted THIO-101's strong survival data and durable partial responses, assigning a $10.27 valuation and emphasizing the importance of (MAIA)'s collaboration with Roche. Meanwhile, Noble Capital Markets analyst Robert LeBoyer reaffirmed an Outperform rating with a $14 target—suggesting more than 700% upside potential from this week's range.
Beyond analyst recognition, the science itself continues to speak louder. This isn't just a lab concept. (MAIA)'s work is already generating peer-reviewed recognition, regulatory incentives, and validation from some of the largest names in oncology. Most recently, interim results from its Phase 2 THIO-101 trial were published in Cells, one of the field's most respected journals—shining a global spotlight on the company's approach. Meanwhile, clinical-supply agreements with Regeneron, BeiGene, and Roche are extending THIO's reach into combinations with some of the most widely used checkpoint inhibitors in the world. The company's clinical story also gained new momentum in recent weeks. Positive Phase 2 Results: At the 2025 IASLC World Conference on Lung Cancer, (MAIA) presented new efficacy data from its ongoing THIO-101 trial evaluating THIO (ateganosine) sequenced with Regeneron's Libtayo® (cemiplimab) in patients with advanced NSCLC who had progressed after multiple prior therapies. The combination delivered a median progression-free survival (PFS) of 5.6 months—more than double the standard 2.5 months for this population—alongside a median overall survival (OS) of 17.8 months, roughly 5.8 months longer than the highest real-world benchmarks. The disease control rate (DCR) reached 77%, compared to the 25–35% typically seen with chemotherapy, and safety remained manageable, with most adverse events classified as Grade 1 or 2. Two patients have now completed 33 treatment cycles, signaling encouraging durability that may translate into longer survival. "THIO-101 continues to reveal impressive efficacy with progression-free survival more than double the standard of care," noted Vlad Vitoc, M.D., MAIA's Chairman and CEO. "We're seeking further validation of these results in our Phase 2 expansion trial, which began enrolling new patients in July 2025."
Taken together, these data strengthen (MAIA)'s position as a front-runner in telomere-targeting immunotherapy—and further explain why both analysts and major partners are taking notice. These encouraging outcomes have set the stage for what's next. (MAIA)'s ongoing and upcoming trials reflect a clear strategy to validate THIO across multiple indications. Clinical Momentum
THIO-101 (Phase 2, NSCLC): Updated interim data presented at the 2025 IASLC World Conference on Lung Cancer showed a median overall survival (OS) of 17.8 months—far exceeding the typical 5–6 months seen with chemotherapy—and a median progression-free survival (PFS) of 5.6 months. Several patients have now surpassed the two-year survival mark, underscoring the durability and consistency of THIO's therapeutic effect. The Phase 2 expansion of THIO-101 began enrolling new patients in July 2025, aiming to further validate efficacy and safety in a broader U.S. patient population. THIO-104 (Phase 3, NSCLC): A pivotal late-stage trial is now underway comparing THIO + Libtayo® (cemiplimab) against physician's-choice chemotherapy. The study is designed to confirm the survival advantage seen in THIO-101, with interim data expected to potentially support accelerated approval in 2026. THIO-102 (Upcoming): Planned expansion into small-cell lung cancer (SCLC), hepatocellular carcinoma (HCC), and colorectal cancer (CRC) remains on track, supported by multiple FDA Orphan Designations already secured for select tumor types. These programs aim to extend THIO's telomere-targeting approach into additional high-need indications. A Pipeline Designed for Depth, Durability, and Reach
While THIO-101 has drawn attention for survival outcomes that continue to exceed benchmarks, (MAIA)'s broader development strategy extends far beyond a single trial. The company is advancing a multi-program pipeline of telomere-targeting therapies across multiple cancers and stages of development: - THIO-104 (NSCLC, 3L): A pivotal Phase 3 trial now underway, pairing ateganosine (THIO) with Regeneron's Libtayo® (cemiplimab). Designed to confirm survival advantages seen in earlier studies, interim data could potentially support accelerated approval in 2026.
- THIO-101 (NSCLC, 2L+): Ongoing Phase 2 expansion now enrolling additional patients in the U.S., following promising results showing a median OS of 17.8 months and PFS of 5.6 months.
- THIO-102 Series (CRC, HCC, SCLC): Planned Phase 2 trials evaluating THIO in combination with BeiGene's tislelizumab (Tevimbra®) to extend its telomere-targeting approach into additional tumor types. Several of these indications already hold FDA Orphan Designations.
- THIO-103 (NSCLC 1L, SCLC 1L): A Phase 2/3 trial in design, intended to bring THIO into earlier treatment lines.
Beyond its lead programs, (MAIA) is developing a second-generation suite of telomere-targeting agents—including MAIA-2021-020, MAIA-2022-012, and MAIA-2021-029—engineered for multiple tumor types. These next-wave candidates are fully owned, developed in-house, and advancing through IND-enabling studies. Taken together, this expanding pipeline underscores that (MAIA) is not a one-trial story—it is building a telomere-targeting oncology platform Regulatory Edge
(MAIA) holds three FDA Orphan Designations—covering liver, lung, and brain cancers—along with a Rare Pediatric Disease Designation. These designations could provide extended market exclusivity and potential access to a priority review voucher, both highly valuable assets in oncology development. The company also continues to strengthen its global patent estate, with protections surrounding its telomere-targeting technology extending well into the 2030s and 2040s. The Big Picture
MAIA Biotechnology (NYSE American: MAIA) is transitioning from clinical promise to visible validation. Recent peer-reviewed publication in Cells, positive efficacy data from the THIO-101 Phase 2 trial, and a $2.3M NIH grant expanding its study footprint have positioned (MAIA) as a recognized innovator in telomere-targeted immunotherapy. With durable survival data, multiple FDA designations, strategic collaborations with Roche, Regeneron, and BeiGene, and analyst coverage pointing to substantial potential revaluation, (MAIA) is steadily carving a space in modern oncology that continues to draw attention. And when you break it down, the story only gets more exciting. 7 Reasons Why (MAIA) Just Hit Our Watchlist This Morning
—Tuesday, October 7, 2025 1. Limited Float: With fewer than 25M shares in its public float, (MAIA) has the potential for notable movement as interest begins to build. 2. Early Momentum: Since our previous coverage, (MAIA) has made an approximate 24% move, signaling growing market attention around recent updates. 3. Strong Data: Updated Phase 2 THIO-101 results showed a median overall survival of 17.8 months and progression-free survival of 5.6 months, both exceeding standard benchmarks. 4. Expanding Pipeline: (MAIA) is advancing four active programs across lung, liver, and colorectal cancers—plus a next-generation suite of telomere-targeting agents in preclinical development. 5. Global Partnerships: Supply agreements with Roche, Regeneron, and BeiGene extend (MAIA)'s reach across multiple late-stage oncology programs. 6. Analyst Recognition: Coverage from Diamond Equity Research and Noble Capital Markets highlights (MAIA)'s data strength and assigns valuations suggesting up to 700% potential revaluation from recent levels. 7. Regulatory Foundation: With three FDA Orphan Designations and a Rare Pediatric Disease Designation, (MAIA) holds incentives that could enhance long-term development and exclusivity Take A Look At (MAIA) Before The Bell Rings…
Company Website | Corporate Presentation
With a low float under 25M shares, that's still trending below $2, and analyst targets projecting as high as $14, which suggest more than 700% upside potential, MAIA Biotechnology (NYSE American: MAIA) has quickly landed on our radar. Layer in Phase 2 survival data that outpaces benchmarks, supply agreements with Roche, Regeneron, and BeiGene, a broad pipeline spanning multiple tumor types, and regulatory designations that can help secure exclusivity, and the setup becomes even harder to ignore. This one checks several boxes that make it stand out early. We have all eyes on (MAIA) this morning. Take a look at this while it's still early. Keep an eye out for my next update, it could be here within the next 60–90 minutes.
Sincerely,
Jeff Ackerman
Managing Editor
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